In Brain. We have used the hybrid instrument (Imagent + DCS) to noninvasively and simultaneously detect low frequency oscillations (LFOs) around 0.1 Hz of cerebral blood flow (CBF) and cerebral oxygenation in human prefrontal cortex. We found that CBF, [HbO2] and THC were reliable hemodynamic parameters in detecting LFOs and 70 degree head-up-tilting (HUT) was the most robust and stable protocol for quantifying phase shifts of hemodynamic LFOs (Ran Cheng et al, NeuroImage, 2012). We also found that CBF changes during HUT can be used for the prediction of vasovagal syncope (Ran Cheng at al, Journal of Biomedical Optics, 2014). We also tested the feasibility and sensitivity of the dual-wavelength DCS flow-oximeter in patients undergoing carotid endarterectomy (Yu Shang et al, Physics in Medicine and Biology, 2011), in mice with stroke (Yu Shang et al, Optics Express, 2011; Lei Chen et al, Journal of Experimental Stroke and Translational Medicine, 2012).
In Muscle. We have tested our optical instrument in skeletal muscles of humans and mice for the diagnosis of diseases (peripheral arterial disease (PAD), fibromyalgia, hypercholesterolemia), and for the monitoring of treatments (arterial revascularization, massage, electrical stimulation). More than 10 peer-reviewed papers have been published from our group to report our studies in muscle.
In Tumor. We have tested our optical instrument for the diagnosis and therapeutic monitoring of tumors (human breast, human head/neck with chemo-radiation therapy, mouse mammary). Results will be published shortly.